Ka helu helu: 330784-47-9 Molecular Formula: C23H26ClN7O3

ʻO ka wehewehe pōkole:

Ka helu helu: 330784-47-9

Inoa Kimia:

Ke Kumu Molekala:C23H26ClN7O3

Manaʻo like:(S)-2-(2-Hydroxymethyl-1-pyrrolidinyl)-4-(3-chloro-4-methoxybenzylamino)-5-[(2-pyrimidinylmethyl)carbamoyl]pyrimidine

4-[(3-Chloro-4-methoxybenzyl)amino]-2-[2-(hydroxymethyl)-1-pyrrolidinyl]-N-(2-pyrimidinylmethyl)-5-pyrimidinecarboxamide

E hoʻouna i ka leka uila iā mākou

Huahana Huahana

Lae hehee	150-152°C
ʻO ka mānoanoa	1.372
ka mahana mālama	Hoʻopaʻa ʻia i kahi maloʻo, E mālama i loko o ka pahu hau, ma lalo o -20 ° C
hikiwawe	DMSO (Lili iki), Methanol (Lili'ili, Wela)
hana ʻōpika	N/A
Ka nana aku	Keʻokeʻo i ke Keʻokeʻo
Maemae	≥98%

pharmacodynamics

(Zepeed) ua ʻae ʻia e ke Keʻena Ola Ola Korea no ka mālama ʻana i ka erectile dysfunction (ED) i ʻAukake 2011. ʻo ia ka mea koho nui 5 phosphodiesterase (PDE5) inhibitor.ua hōʻike ʻia ʻo ia ka mea koho PDE5 inhibitor ma ka mākeke.ʻO ka hoʻomaka ʻana o Tmax a me ka hapalua o ke ola ʻokoʻa i waena o nā mea kūʻai aku PDE5 inhibitors.Loaʻa iā Sildenafil kahi T_maxma 1 h a me ka hapalua o ke ola o 3-5 h.He ʻano like ʻo Vardenafil me kahi T_maxo 0.6 h a me ka hapalua-ola o 4-6 h.ʻO Tadalafil ka lōʻihi o ka hapalua o ke ola ma waena o nā lāʻau lapaʻau kūʻai me ka hapalua o ke ola o 17 h.Loaʻa ka hoʻomaka wikiwiki o ka hana a hiki i T_maxi 0.6 h me ka hapalua o ke ola o 1.2 h.Ua wehewehe ʻia kahi synthesis o (TA-1790) ma ka palapala patent.ʻO ke ala nui e hoʻopau ai ma o ka bile a me nā feces.ua ʻike ʻia hoʻi e hoʻihoʻi ʻia ma o ka recirculation enterohepatic.