Helu Cas: 54-31-9 Huina Molekula:C12H11ClN2O5S
| Lae hehee | 261-263°C |
| ʻO ka mānoanoa | 1.16 (manaʻo koʻikoʻi) |
| ka mahana mālama | ʻO ka lewa inert, lumi wela 2-8°C |
| hikiwawe | DMSO: >5 mg/mL ma 60 °C |
| hana ʻōpika | N/A |
| Ka nana aku | Paʻa Keʻokeʻo Paʻa |
| Maemae | ≥98% |
Ua hoʻokuʻu ʻia ʻo Telmisartan ma US no ka mālama ʻana i ka hypertension.Hiki ke hoʻomākaukau ʻia ma nā ʻanuʻu ʻewalu e hoʻomaka ana me ka methyl 4-amino-3-methyl benzoate;ʻO ka mua a me ka lua o ka cyclization i loko o ke apo benzimidazole e hana ʻia ma nā ʻanuʻu 4 a me 6.Hoʻopaʻa ʻo Telmisartan i ka hana o ka angiotensin II (Ang II), ka molekele hopena mua o ka ʻōnaehana renin-angiotensin-aldosterone (RAAS).ʻO ia ke ono o kēia papa 《sartans》 e kūʻai ʻia ma hope o ka hui alakaʻi Losartan.ʻO kona hopena lōʻihi (24h half-life) hiki ke ʻokoʻa nui me nā antagonist angiotensin II ʻē aʻe.ʻAʻole like me nā mea ʻē aʻe o kēia ʻāpana, ʻaʻole hilinaʻi kāna hana i ka hoʻololi ʻana i kahi metabolite ikaika, ʻo ka 1-O-acylglucuronide ka metabolite nui i loaʻa i loko o ke kanaka.ʻO Telmisartan kahi antagonist hoʻokūkū ikaika o nā mea loaʻa AT1 e hoʻoponopono i ka hapa nui o nā hopena koʻikoʻi o ka angiotensin II me ka nele o ka pilina no nā subtypes AT2 a i ʻole nā mea hoʻokipa ʻē aʻe e pili ana i ka hoʻoponopono cardiovascular.I loko o kekahi mau noiʻi lapaʻau, ʻo Telmisartan, i ka manawa hoʻokahi i kēlā me kēia lā, ua hana maikaʻi a hoʻomau i ka hoʻohaʻahaʻa ʻana i ke koko me ka haʻahaʻa o nā hopena ʻaoʻao (ʻoi aku ka maʻi pili i ka mālama ʻana i pili me nā ACE inhibitors i nā poʻe maʻi ʻelemakule).
ʻO Telmisartan kahi antagonist receptor angiotensin II.
