Rifampicin Ka helu helu:13292-46-1 Molecular Formula: C43H58N4O12

ʻO Rifampicin he semisynthetic derivative o rifamicin B, he macrolactam antibiotic a me kekahi o ʻoi aku ma mua o ʻelima mau lāʻau antibiotic mai ka hui ʻana o rifamicins A, B, C, D, a me E, i kapa ʻia he rifamicin complex, i hana ʻia e actinomycetes Streptomyces mediteranei ( Nocardia mediteranei).Ua hoʻokomo ʻia i loko o ka hoʻomaʻamaʻa lapaʻau i ka makahiki 1968. Hoʻomaka ka synthesis o ka rifampicin me kahi hoʻonā wai o rifamicin, a ma lalo o nā ʻano hopena i oxidized i kahi derivative hou o rifamicin S (32.7.4), me ka hoʻokumu ʻana o rifamicin O (32.7. 3).ʻO ka hōʻemi ʻana i ka hana quinone o kēia huahana me ka hydrogen me ka hoʻohana ʻana i ka palladium ma ka carbon catalyst e hāʻawi ai i ka rifamicin SV (32.7.5).ʻO ka huahana i loaʻa i ka aminomethylation e ka hui ʻana o formaldehyde a me pyrrolidine, e hāʻawi ana i ka 3-pyrrolidinomethylrifamicin SV (32.7.6).ʻO ka oxidizing i ka huahana hopena me ke alakaʻi tetracetate i kahi enamine a me ka hydrolysis ma hope me ka wai wai o ka waikawa ascorbic e hāʻawi ai i ka 3-formylrifamicin SV (32.7.7).ʻO ka pane ʻana i kēia me ka 1-amino-4-methylpiperazine e hāʻawi i ka rifampicin i makemake ʻia (32.7.8).