Ka helu helu: 144701-48-4 Molecular Formula：C33H30N4O2

Ka helu helu: 144701-48-4 Hui Māmā:C33H30N4O2

ʻO ka wehewehe pōkole:

Ka helu helu: 144701-48-4
Inoa Kimia:
Hui Molekala:C33H30N4O2

Synonyms：MICARDIS;TU-199;Telmisaran;TIMISHATAN;2-(4-{[4-Methyl-6-(1-Methyl-1H-1,3-benzodiazol-2-yl)-2-propyl-1H-1 ,3-benzodiazol-1-yl]Methyl}phenyl)benzoic acid;4′[(1,4′-Dimethyl-2′-propyl[2,6′-bi-1H-benzimidazol]-1′-yl)methyl ][1,1′-biphenyl]-2-carboxylic acid, BIBR 277; PRITOR; BIBR 277; misartan; BIBR 277SE

E hoʻouna i ka leka uila iā mākou

Huahana Huahana

Lae hehee	261-263°C
ʻO ka mānoanoa	1.16 (manaʻo koʻikoʻi)
ka mahana mālama	ʻO ka lewa inert, lumi wela 2-8°C
hikiwawe	DMSO: >5 mg/mL ma 60 °C
hana ʻōpika	N/A
Ka nana aku	Paʻa Keʻokeʻo Paʻa
Maemae	≥98%

wehewehe

ua hoʻomaka ʻia ma ka US no ka mālama ʻana i ka hypertension.Hiki ke hoʻomākaukau ʻia ma nā ʻanuʻu ʻewalu e hoʻomaka ana me ka methyl 4-amino-3-methyl benzoate;ʻO ka mua a me ka lua o ka cyclization i loko o ke apo benzimidazole e hana ʻia ma nā ʻanuʻu 4 a me 6.pale i ka hana a ka angiotensin II (Ang II), ka molekele hopena mua o ka renin-angiotensin-aldosterone system (RAAS).ʻO ia ke ono o kēia papa 《sartans》 e kūʻai ʻia ma hope o ka hui alakaʻi Losartan.ʻO kona hopena lōʻihi (24h half-life) hiki ke ʻokoʻa nui me nā antagonist angiotensin II ʻē aʻe.ʻAʻole like me nā mea ʻē aʻe o kēia ʻāpana, ʻaʻole hilinaʻi kāna hana i ka hoʻololi ʻana i kahi metabolite ikaika, ʻo ka 1-O-acylglucuronide ka metabolite nui i loaʻa i loko o ke kanaka. angiotensin II me ka nele i ka pilina no nā subtype AT2 a i ʻole nā mea hoʻokipa ʻē aʻe e pili ana i ka hoʻoponopono cardiovascular.I loko o kekahi mau noiʻi lapaʻau, i ka manawa hoʻokahi i kēlā me kēia lā, ua hana maikaʻi a hoʻomau i nā hopena hoʻohaʻahaʻa i ke koko me ka liʻiliʻi o nā hopena ʻaoʻao (ʻoi aku ka maʻi pili pili i ka mālama ʻana i pili me nā ACE inhibitors i nā poʻe maʻi ʻelemakule).