Ka helu helu: 147403-03-0 Māmā Molekula: C24H29N5O3
| Lae hehee | 230°C |
| ʻO ka mānoanoa | 1.41g/cm³ |
| ka mahana mālama | 2-8 ℃ |
| hikiwawe | ʻAʻole hiki ke hoʻoheheʻe ʻia i ka wai, a ʻo ka solubility i ka ethanol he 5.5 mg/m |
| hana ʻōpika | +76.5 degere (C=1, ethanol) |
| Ka nana aku | keʻokeʻo a keʻokeʻo keʻokeʻo paʻa, ʻaʻala ʻole |
he peptide ʻole, ʻoi aku ka maikaʻi o ka angiotensin II (AT) receptor antagonist.Loaʻa iā ia ke koho kiʻekiʻe i ke ʻano I receptor (AT1) a hiki ke hoʻokūkū kūʻē me ka ʻole o nā hopena hoʻoulu.Hiki iā ia ke kaohi i ka hoʻokuʻu ʻana o ka aldosterol i hoʻokuʻu ʻia i ka AT1 mai nā pūnaewele glomerular adrenal, akā ʻaʻohe hopena paʻa i ka hoʻokuʻu ʻana i ka potassium, e hōʻike ana i kona hopena koho i nā mea loaʻa AT1.Ua hōʻike ʻia nā hoʻokolohua in vivo i nā ʻano hiʻohiʻona holoholona hypertension he hopena antihypertensive maikaʻi a ʻaʻohe hopena koʻikoʻi i ka hana contractile cardiac a me ka puʻuwai puʻuwai.ʻAʻohe hopena antihypertensive i nā holoholona me ke koko maʻamau
Nā lāʻau antihypertensive.he angiotensin II (Ang II) receptor antagonist e ālai pono ana i ka hoʻopaʻa ʻana o Ang II i nā mea loaʻa AT1 (ʻo kona hopena antagonistic kikoʻī i nā mea loaʻa AT1 ma kahi o 20000 mau manawa ʻoi aku ka nui ma mua o ka AT2), no laila ke kāohi nei i ka hoʻopaʻapaʻa vascular a me ka hoʻokuʻu ʻana o ka aldosterone. nā hopena hypotensive
ʻO ka nui o ka hoʻomaka ʻana no nā papa he 80mg (2 papa), lawe waha ʻia i hoʻokahi lā.ʻO ka maʻamau, inā ʻaʻole pono no 4 mau pule, hiki ke hoʻonui ʻia ka dosage i 160mg (4 papa) hoʻokahi i ka lā.Wahi a ka ʻikepili noiʻi lapaʻau haole, hiki i ka nui o ka nui ke hiki i 320mg (8 papa) hoʻokahi i ka lā
1. ʻO nā maʻi me ka hypertension paʻakikī me ka maʻi diabetes, hypertension paʻakikī me ka nephropathy a i ʻole ka maʻi diabetes nephropathy,
2. nā maʻi me ke kiʻekiʻe kiʻekiʻe paʻakikī me ka puʻuwai hāʻule a i ʻole myocardial infarction
