Ka helu helu: 224785-91-5 Ke Kumu Molekula:C23H33ClN6O4S
| Lae hehee | 214-216°C |
| ʻO ka mānoanoa | N/A |
| ka mahana mālama | Ka lewa ʻole, 2-8°C |
| hikiwawe | N/A |
| hana ʻōpika | N/A |
| Ka nana aku | Keʻokeʻo i ka Cyrstalline Keʻokeʻo |
| Maemae | ≥98% |
ʻO ia ka lua o ka lāʻau i kūʻai ʻia a loaʻa iā ia ka pōmaikaʻi ʻaʻole i hoʻemi ʻia kona manawa hoʻomaka ma ka lawe ʻana i ka lāʻau i ka ʻōpū piha.ʻO 30 mau manawa iʻoi aku ka ikaika ma keʻano he mea hoʻopaneʻe o PDE5 (mean IC50, 3.9 nM) ma mua o ka sildenafil a me ka 10 manawa iʻoi aku ka ikaika ma mua o tadalafil, me ka koho nui (> 1,000 manawa) no ke kanaka PDE5 ma mua o ke kanaka PDE2, PDE3, a me PDE4 a koho haʻahaʻa (> 80 manawa) no PDE1.ʻO ka PDE inhibitory selectivity a me ka in vitro a me ka in vivo potency o ka PDE5 inhibitor hou.ua pale pono i ka hydrolysis o cGMP e PDE5, me kahi IC50 o 0.7 nM (sildenafil 6.6 nM).ʻO ka IC50 o no PDE1 he 180 nM, no PDE6 11 nM, a no PDE2, PDE3 a me PDE4 ʻoi aku ma mua o 1,000 nM.
He phsphodiesterase type 5 (PDE5) mea hoʻopaneʻe koho
ʻŌlelo ke kauka no ka hoʻohana ʻana
