Helu Cetilistat Cas: 282526-98-1 Molecular Formula:C25H39NO3
| Lae hehee | 72.0 a i 76.0 °C |
| ʻO ka mānoanoa | 1.02 |
| ka mahana mālama | Hoʻopaʻa ʻia i kahi maloʻo, 2-8 ° C |
| hikiwawe | Chloroform (Liʻiliʻi), Ethyl Acetate (Liʻiliʻi) |
| hana ʻōpika | N/A |
| Ka nana aku | Poe keʻokeʻo keʻokeʻo |
| Maemae | ≥98% |
Ua ʻae ʻia ʻo Cetilistat (i ʻike ʻia ʻo ATL-962) i Kepakemapa 2013 e ke Keʻena ʻOihana Ola, Labour a Welfare o Iapana no ka mālama ʻana i ka momona, i kaupalena ʻia i nā poʻe maʻi me ka type 2 diabetes mellitus (T2DM) a me ka dyslipidemia, a me ka nui o ke kino. helu helu (BMI)25 kg/m2ʻoiai ka mālama ʻana i ka meaʻai a/a i ʻole ka hoʻoikaika kino.E like me ka orlistat, hana ka cetilistat ma o ka pale ʻana i nā lipases pancreatic i loko o ka ʻōpū e pale ai i ka hoʻopili ʻana i ka momona a no laila e hōʻemi i ka lawe ʻana i ka caloric mai ka meaʻai.ʻAʻole i wehewehe ʻia ka papahana kemika lāʻau lapaʻau ma ka palapala ʻepekema, akā ʻo ka patent e wehewehe ana i ka cetilistat e wehewehe pū ana i ka synthesis o nā analogs me nā ʻano aril a me nā huelo lipophilic.ʻO ka synthesis o ka cetilistat e pili ana i ka condensation o kahi hexadecylcarbonochloridate me ka 2-amino-5-methylbenzoic acid;ua hoʻohui ʻia nā analogs ʻē aʻe e ka hoʻololi ʻana i ka carbonochloridate a me 2-aminobenzoic acid component.ʻO Cetilistat kahi mea paʻa ikaika o ke kanaka a me ka ʻiole pancreatic lipase me IC50sʻO 15 a me 136 nM, kēlā me kēia, me ka liʻiliʻi o ka trypsin a i ʻole chymotrypsin.
ʻO kahi mea hoʻopaneʻe pancreatic lipase no ka mālama ʻana i ka momona i nā maʻi maʻi maʻi a me nā maʻi maʻi ʻole.
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